Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity

The Fc receptor on NK cells, FcγRIIIA (CD16), has been extensively studied for its role in mediating antibody-dependent cellular cytotoxicity (ADCC). A homozygous missense mutation in CD16 (encoding a L66H substitution) is associated with severe herpesvirus infections in rare patients. Here, we iden...

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Détails bibliographiques
Auteurs principaux: Grier, Jennifer T., Forbes, Lisa R., Monaco-Shawver, Linda, Oshinsky, Jennifer, Atkinson, T. Prescott, Moody, Curtis, Pandey, Rahul, Campbell, Kerry S., Orange, Jordan S.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461929/
https://ncbi.nlm.nih.gov/pubmed/23006327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64837
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