Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity

Haploinsufficiency for GATA2 causes human immunodeficiency syndromes characterized by mycobacterial infection, myelodysplasia, lymphedema, or aplastic anemia that progress to myeloid leukemia. GATA2 encodes a master regulator of hematopoiesis that is also linked to endothelial biology. Though the di...

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Autors principals: Johnson, Kirby D., Hsu, Amy P., Ryu, Myung-Jeom, Wang, Jinyong, Gao, Xin, Boyer, Meghan E., Liu, Yangang, Lee, Youngsook, Calvo, Katherine R., Keles, Sunduz, Zhang, Jing, Holland, Steven M., Bresnick, Emery H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461907/
https://ncbi.nlm.nih.gov/pubmed/22996659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61623
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