Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2

Disease mutations provide unique opportunities to decipher protein and cell function. Mutations in the master regulator of hematopoiesis GATA-2 underlie an immunodeficiency associated with myelodysplastic syndrome and leukemia. We discovered that a GATA-2 disease mutant (T354M) defective in chromati...

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Autores principales: Katsumura, Koichi R, Yang, Chenxi, Boyer, Meghan E, Li, Lingjun, Bresnick, Emery H
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Scientific Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198037/
https://ncbi.nlm.nih.gov/pubmed/25056917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438808
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