Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning

The transcription factor GATA-2 plays vital roles in quite diverse developmental programs, including hematopoietic stem cell (HSC) survival and proliferation. We previously identified a vascular endothelial (VE) enhancer that regulates GATA-2 activity in pan-endothelial cells. To more thoroughly def...

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Bibliographic Details
Main Authors: Lim, Kim-Chew, Hosoya, Tomonori, Brandt, William, Ku, Chia-Jui, Hosoya-Ohmura, Sakie, Camper, Sally A., Yamamoto, Masayuki, Engel, James Douglas
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461906/
https://ncbi.nlm.nih.gov/pubmed/22996665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61619
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