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Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells
mTORC1 inhibitors, including rapamycin and its analogs, have been actively studied both pre-clinically and clinically. However, the single treatment of mTORC1 inhibitors has been modest in most cancer types. We have previously demonstrated that the activation of PI3K/Akt and MEK/ERK signaling pathwa...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Landes Bioscience
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3461807/ https://ncbi.nlm.nih.gov/pubmed/22825337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.20989 |
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