IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa

Interleukin-7 (IL-7) is a nonredundant cytokine that plays a critical role in T-cell homeostasis and promotes immunologic reconstitution in lymphopenic hosts. Here, we show that IL-7, at doses that reflect suprahomeostatic concentrations achieved in lymphopenic hosts, is a potent and selective induc...

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Detalhes bibliográficos
Main Authors: Cimbro, Raffaello, Vassena, Lia, Arthos, James, Cicala, Claudia, Kehrl, John H., Park, Chung, Sereti, Irini, Lederman, Michael M., Fauci, Anthony S., Lusso, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460683/
https://ncbi.nlm.nih.gov/pubmed/22896005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-434779
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