Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing

The intestinal mucosa is a key anatomical site for HIV-1 replication and CD4(+) T-cell depletion. Accordingly, in vivo treatment with an antibody to the gut-homing integrin α4β7 was shown to reduce viral transmission, delay disease progression, and induce persistent virus control in macaques challen...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Immunol
Auteurs principaux: Guzzo, Christina, Ichikawa, David, Park, Chung, Phillips, Damilola, Liu, Qingbo, Zhang, Peng, Kwon, Alice, Miao, Huiyi, Lu, Jacky, Rehm, Catherine, Arthos, James, Cicala, Claudia, Cohen, Myron S., Fauci, Anthony S., Kehrl, John H., Lusso, Paolo
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653278/
https://ncbi.nlm.nih.gov/pubmed/28763793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aam7341
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