Structural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys(165)

Clostridium botulinum neurotoxin type A (BoNT/A) is one of the most potent toxins for humans and a major biothreat agent. Despite intense chemical efforts over the past 10 years to develop inhibitors of its catalytic domain (catBoNT/A), highly potent and selective inhibitors are still lacking. Recen...

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Detalhes bibliográficos
Main Authors: Stura, Enrico A., Le Roux, Laura, Guitot, Karine, Garcia, Sandra, Bregant, Sarah, Beau, Fabrice, Vera, Laura, Collet, Guillaume, Ptchelkine, Denis, Bakirci, Huseyin, Dive, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460459/
https://ncbi.nlm.nih.gov/pubmed/22869371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.396697
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