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Extracellular pH Regulates Zinc Signaling via an Asp Residue of the Zinc-sensing Receptor (ZnR/GPR39)

Zinc activates a specific Zn(2+)-sensing receptor, ZnR/GPR39, and thereby triggers cellular signaling leading to epithelial cell proliferation and survival. Epithelial cells that express ZnR, particularly colonocytes, face frequent changes in extracellular pH that are of physiological and pathologic...

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Autors principals: Cohen, Limor, Asraf, Hila, Sekler, Israel, Hershfinkel, Michal
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460437/
https://ncbi.nlm.nih.gov/pubmed/22879599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372441
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