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Soluble Prion Protein Inhibits Amyloid-β (Aβ) Fibrillization and Toxicity
The pathogenesis of Alzheimer disease appears to be strongly linked to the aggregation of amyloid-β (Aβ) peptide and, especially, formation of soluble Aβ1–42 oligomers. It was recently demonstrated that the cellular prion protein, PrP(C), binds with high affinity to these oligomers, acting as a puta...
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| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3460415/ https://ncbi.nlm.nih.gov/pubmed/22915585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.400614 |
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