Binding of Trastuzumab to ErbB2 Is Inhibited by a High Pericellular Density of Hyaluronan

Although trastuzumab is an efficient drug, primary and acquired resistance is a challenging problem. The authors have previously shown in mouse xenograft experiments that masking ErbB2 by hyaluronan leads to diminished binding of the antibody and consequent resistance. In the current work, they corr...

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Autors principals: Váradi, Tímea, Mersich, Tamás, Auvinen, Päivi, Tammi, Raija, Tammi, Markku, Salamon, Ferenc, Besznyák, István, Jakab, Ferenc, Baranyai, Zsolt, Szöllősi, János, Nagy, Peter
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publications 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460360/
https://ncbi.nlm.nih.gov/pubmed/22562558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/0022155412448070
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