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Binding of Trastuzumab to ErbB2 Is Inhibited by a High Pericellular Density of Hyaluronan
Although trastuzumab is an efficient drug, primary and acquired resistance is a challenging problem. The authors have previously shown in mouse xenograft experiments that masking ErbB2 by hyaluronan leads to diminished binding of the antibody and consequent resistance. In the current work, they corr...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3460360/ https://ncbi.nlm.nih.gov/pubmed/22562558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/0022155412448070 |
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