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Ultrashort and progressive 4sU-tagging reveals key characteristics of RNA processing at nucleotide resolution

RNA synthesis and decay rates determine the steady-state levels of cellular RNAs. Metabolic tagging of newly transcribed RNA by 4-thiouridine (4sU) can reveal the relative contributions of RNA synthesis and decay rates. The kinetics of RNA processing, however, had so far remained unresolved. Here, w...

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Detalhes bibliográficos
Main Authors: Windhager, Lukas, Bonfert, Thomas, Burger, Kaspar, Ruzsics, Zsolt, Krebs, Stefan, Kaufmann, Stefanie, Malterer, Georg, L'Hernault, Anne, Schilhabel, Markus, Schreiber, Stefan, Rosenstiel, Philip, Zimmer, Ralf, Eick, Dirk, Friedel, Caroline C., Dölken, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460197/
https://ncbi.nlm.nih.gov/pubmed/22539649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.131847.111
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