4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response

High concentrations (> 100 µM) of the ribonucleoside analog 4-thiouridine (4sU) is widely used in methods for RNA analysis like photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) and nascent messenger (m)RNA labeling (4sU-tagging). Here, we show that 4sU-tagg...

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Detalhes bibliográficos
Main Authors: Burger, Kaspar, Mühl, Bastian, Kellner, Markus, Rohrmoser, Michaela, Gruber-Eber, Anita, Windhager, Lukas, Friedel, Caroline C, Dölken, Lars, Eick, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866244/
https://ncbi.nlm.nih.gov/pubmed/24025460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.26214
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