Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

Drugs for cancer therapy belong to different categories of chemical substances. The cellular targets for the therapeutic efficacy are often not unambiguously identified. Here, we describe the process of ribosome biogenesis as a target of a large variety of chemotherapeutic drugs. We determined the i...

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Bibliographische Detailangaben
Hauptverfasser: Burger, Kaspar, Mühl, Bastian, Harasim, Thomas, Rohrmoser, Michaela, Malamoussi, Anastassia, Orban, Mathias, Kellner, Markus, Gruber-Eber, Anita, Kremmer, Elisabeth, Hölzel, Michael, Eick, Dirk
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852979/
https://ncbi.nlm.nih.gov/pubmed/20159984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074211
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