Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations

X chromosome inactivation (XCI) achieves dosage balance in mammals by repressing one of two X chromosomes in females. During XCI, the long noncoding Xist RNA and Polycomb proteins spread along the inactive X (Xi) to initiate chromosome-wide silencing. Although inactivation is known to commence at th...

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Autors principals: Pinter, Stefan F., Sadreyev, Ruslan I., Yildirim, Eda, Jeon, Yesu, Ohsumi, Toshiro K., Borowsky, Mark, Lee, Jeannie T.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460182/
https://ncbi.nlm.nih.gov/pubmed/22948768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.133751.111
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