Application of a Novel Strategy of Engineering Conditional Alleles to a Single Exon Gene, Sox2

BACKGROUND: The Conditional by Inversion (COIN) method for engineering conditional alleles relies on an invertible optimized gene trap-like element, the COIN module, for imparting conditionality. The COIN module contains an optimized 3′ splice site-polyadenylation signal pair, but is inserted antise...

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Bibliografiske detaljer
Main Authors: Mandalos, Nikolaos, Saridaki, Marannia, Harper, Jessica Lea, Kotsoni, Anastasia, Yang, Peter, Economides, Aris N., Remboutsika, Eumorphia
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459942/
https://ncbi.nlm.nih.gov/pubmed/23029233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045768
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