Sox2 acts as a rheostat of epithelial to mesenchymal transition during neural crest development

Precise control of self-renewal and differentiation of progenitor cells into the cranial neural crest (CNC) pool ensures proper head development, guided by signaling pathways such as BMPs, FGFs, Shh and Notch. Here, we show that murine Sox2 plays an essential role in controlling progenitor cell beh...

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Autori principali: Nikolaos eMandalos, Muriel eRhinn, Zoraide eGranchi, Ioannis eKarampelas, Thimios eMitsiadis, Aris eEconomides, Pascal eDolle, Eumorphia eRemboutsika
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2014-09-01
Serie:Frontiers in Physiology
Soggetti:
Head
Stem Cells
Tooth
Craniofacial Development
neural progenitors
Sox genes
Accesso online:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00345/full
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