Direct Binding of Occupied Urokinase Receptor (uPAR) to LDL Receptor-related Protein Is Required for Endocytosis of uPAR and Regulation of Cell Surface Urokinase Activity

Low-density lipoprotein receptor-related protein (LRP) mediates internalization of urokinase:plasminogen activator inhibitor complexes (uPA:PAI-1) and the urokinase receptor (uPAR). Here we investigated whether direct interaction between uPAR, a glycosyl-phosphatidylinositol–anchored protein, and LR...

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Hauptverfasser: Czekay, Ralf-Peter, Kuemmel, Thomas A., Orlando, Robert A., Farquhar, Marilyn Gist
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2001
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC34598/
https://ncbi.nlm.nih.gov/pubmed/11359936
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