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Induction of Novel Agonist Selectivity for the ADP-Activated P2Y(1) Receptor Versus the ADP-Activated P2Y(12) and P2Y(13) Receptors by Conformational Constraint of an ADP Analog

ADP is the cognate agonist of the P2Y(1), P2Y(12), and P2Y(13) receptors. With the goal of identifying a high potency agonist that selectively activates the P2Y(1) receptor, we examined the pharmacological selectivity of the conformationally constrained non-nucleotide analog (N)-methanocarba-2MeSADP...

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Autors principals: Chhatriwala, Mariya, Ravi, R. Gnana, Patel, Roshni I., Boyer, Jose L., Jacobson, Kenneth A., Harden, T. Kendall
Format: Artigo
Idioma:Inglês
Publicat: 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3459333/
https://ncbi.nlm.nih.gov/pubmed/15345752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.104.068650
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