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Induction of Novel Agonist Selectivity for the ADP-Activated P2Y(1) Receptor Versus the ADP-Activated P2Y(12) and P2Y(13) Receptors by Conformational Constraint of an ADP Analog
ADP is the cognate agonist of the P2Y(1), P2Y(12), and P2Y(13) receptors. With the goal of identifying a high potency agonist that selectively activates the P2Y(1) receptor, we examined the pharmacological selectivity of the conformationally constrained non-nucleotide analog (N)-methanocarba-2MeSADP...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3459333/ https://ncbi.nlm.nih.gov/pubmed/15345752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.104.068650 |
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