Expression of a cloned adenovirus gene is inhibited by in vitro methylation.
In many viral and nonviral eukaryotic systems, an inverse correlation has been observed between the extent of DNA methylation at 5'-C-C-G-G-3' sites and the extent of expression of specific genes as mRNA. The E2a region of adenovirus serotype 2 (Ad2) DNA encodes the Ad2-specific DNA binding protein...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
1982
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC345902/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6951163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.4.1073 |
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