Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats

BACKGROUND: Recurrent/moderate (R/M) hypoglycemia is common in type 1 diabetes. Although mild or moderate hypoglycemia is not life-threatening, if recurrent, it may cause cognitive impairment. In the present study, we sought to determine whether R/M hypoglycemia leads to neuronal death, dendritic in...

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Hauptverfasser: Won, Seok Joon, Yoo, Byung Hoon, Kauppinen, Tiina M, Choi, Bo Young, Kim, Jin Hee, Jang, Bong Geom, Lee, Min Woo, Sohn, Min, Liu, Jialing, Swanson, Raymond A, Suh, Sang Won
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458941/
https://ncbi.nlm.nih.gov/pubmed/22830525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-182
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