Heterologous Prime-Boost Regimens Using rAd35 and rMVA Vectors Elicit Stronger Cellular Immune Responses to HIV Proteins Than Homologous Regimens

We characterized prime-boost vaccine regimens using heterologous and homologous vector and gene inserts. Heterologous regimens offer a promising approach that focuses the cell-mediated immune response on the insert and away from vector-dominated responses. Ad35-GRIN/ENV (Ad35-GE) vaccine is comprise...

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Detalhes bibliográficos
Main Authors: Ratto-Kim, Silvia, Currier, Jeffrey R., Cox, Josephine H., Excler, Jean-Louis, Valencia-Micolta, Anais, Thelian, Doris, Lo, Vicky, Sayeed, Eddy, Polonis, Victoria R., Earl, Patricia L., Moss, Bernard, Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Marovich, Mary A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458867/
https://ncbi.nlm.nih.gov/pubmed/23049876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045840
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