Phase I Safety and Immunogenicity Evaluation of MVA-CMDR, a Multigenic, Recombinant Modified Vaccinia Ankara-HIV-1 Vaccine Candidate

BACKGROUND: We conducted a Phase I randomized, dose-escalation, route-comparison trial of MVA-CMDR, a candidate HIV-1 vaccine based on a recombinant modified vaccinia Ankara viral vector expressing HIV-1 genes env/gag/pol. The HIV sequences were derived from circulating recombinant form CRF01_AE, wh...

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Detalhes bibliográficos
Main Authors: Currier, Jeffrey R., Ngauy, Viseth, de Souza, Mark S., Ratto-Kim, Silvia, Cox, Josephine H., Polonis, Victoria R., Earl, Patricia, Moss, Bernard, Peel, Sheila, Slike, Bonnie, Sriplienchan, Somchai, Thongcharoen, Prasert, Paris, Robert M., Robb, Merlin L., Kim, Jerome, Michael, Nelson L., Marovich, Mary A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981570/
https://ncbi.nlm.nih.gov/pubmed/21085591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013983
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