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Asymmetric total synthesis of smyrindiol employing an organocatalytic aldol key step

The first organocatalytic asymmetric synthesis of smyrindiol, by using an (S)-proline catalyzed enantioselective intramolecular aldol reaction as the key step, is described. Smyrindiol was synthesized from commercially available 2,4-dihydroxybenzaldehyde in 15 steps, with excellent stereoselectivity...

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Main Authors: Enders, Dieter, Fronert, Jeanne, Bisschops, Tom, Boeck, Florian
Formáid: Artigo
Teanga:Inglês
Foilsithe: Beilstein-Institut 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458728/
https://ncbi.nlm.nih.gov/pubmed/23019438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.8.123
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