Complex Oncogenic Signaling Networks Regulate Brain Tumor‐Initiating Cells and Their Progenies: Pivotal Roles of Wild‐Type EGFR, EGFRvIII Mutant and Hedgehog Cascades and Novel Multitargeted Therapies

Complex signaling cross‐talks between different growth factor cascades orchestrate the primary brain cancer development. Among the frequent deregulated oncogenic pathways, the ligand‐activated wild‐type epidermal growth factor receptor (EGFR), constitutively activated EGFRvIII mutant and sonic hedge...

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Main Authors: Mimeault, Murielle, Batra, Surinder K.
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2011
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458583/
https://ncbi.nlm.nih.gov/pubmed/21615592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2011.00505.x
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