Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase

Double-strand breaks (DSBs) are repaired by two distinct pathways, non-homologous end joining (NHEJ) and homologous recombination (HR). The endonuclease Artemis and the PIK kinase Ataxia-Telangiectasia Mutated (ATM), mutated in prominent human radiosensitivity syndromes, are essential for repairing...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Köcher, Sabrina, Rieckmann, Thorsten, Rohaly, Gabor, Mansour, Wael Y., Dikomey, Ekkehard, Dornreiter, Irena, Dahm-Daphi, Jochen
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458552/
https://ncbi.nlm.nih.gov/pubmed/22730303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks604
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky