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Rational engineering of sequence specificity in R.MwoI restriction endonuclease

R.MwoI is a Type II restriction endonucleases enzyme (REase), which specifically recognizes a palindromic interrupted DNA sequence 5′-GCNNNNNNNGC-3′ (where N indicates any nucleotide), and hydrolyzes the phosphodiester bond in the DNA between the 7th and 8th base in both strands. R.MwoI exhibits rem...

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Bibliografische gegevens
Hoofdauteurs: Skowronek, Krzysztof, Boniecki, Michal J., Kluge, Boguslaw, Bujnicki, Janusz M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458533/
https://ncbi.nlm.nih.gov/pubmed/22735699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks570
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