A Single-Day Treatment with Mifepristone Is Sufficient to Normalize Chronic Glucocorticoid Induced Suppression of Hippocampal Cell Proliferation

BACKGROUND: Chronic stress or prolonged administration of glucocorticoids suppresses proliferation and/or survival of newborn cells in adult rat dentate gyrus. Earlier we showed that administration of the glucocorticoid receptor antagonist mifepristone during the final 4 days of a 21 days period of...

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Bibliographic Details
Main Authors: Hu, Pu, Oomen, Charlotte, van Dam, Anne-Marie, Wester, Jordi, Zhou, Jiang-Ning, Joëls, Marian, Lucassen, Paul J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458013/
https://ncbi.nlm.nih.gov/pubmed/23049985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046224
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