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Targeted cytosine deaminase-uracil phosphoribosyl transferase suicide gene therapy induces small cell lung cancer specific cytotoxicity and tumor growth delay

PURPOSE: Small cell lung cancer (SCLC) is a highly malignant cancer for which there is no curable treatment and novel therapies are therefore in high demand. In the present study we investigated the therapeutic effect of transcriptionally targeted suicide gene therapy for SCLC based on the yeast cyt...

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Detalhes bibliográficos
Main Authors: Christensen, Camilla L., Gjetting, Torben, Poulsen, Thomas T., Cramer, Frederik, Roth, Jack A., Poulsen, Hans S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457699/
https://ncbi.nlm.nih.gov/pubmed/20371678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3057
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