In vitro and in vivo effects of polyethylene glycol (PEG)-modified lipid in DOTAP/cholesterol-mediated gene transfection

BACKGROUND: DOTAP/cholesterol-based lipoplexes are successfully used for delivery of plasmid DNA in vivo especially to the lungs, although low systemic stability and circulation have been reported. To achieve the aim of discovering the best method for systemic delivery of DNA to disseminated tumors...

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Detalhes bibliográficos
Main Authors: Gjetting, Torben, Arildsen, Nicolai Skovbjerg, Christensen, Camilla Laulund, Poulsen, Thomas Tuxen, Roth, Jack A, Handlos, Vagn Neerup, Poulsen, Hans Skovgaard
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2010
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950395/
https://ncbi.nlm.nih.gov/pubmed/20957159
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