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Single-cell gene expression analyses of cellular reprogramming reveal a stochastic early and hierarchic late phase

During cellular reprogramming only a small fraction of cells become induced pluripotent stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based on populations of cells, impeding single-cell level identification of reprogramming events. We utilized two gene expression...

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Detalhes bibliográficos
Main Authors: Buganim, Yosef, Faddah, Dina A., Cheng, Albert W., Itskovich, Elena, Markoulaki, Styliani, Ganz, Kibibi, Klemm, Sandy L., van Oudenaarden, Alexander, Jaenisch, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457656/
https://ncbi.nlm.nih.gov/pubmed/22980981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.08.023
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