The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection

Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as measured in mice by chimera contribution and tetraploid complementation. Reliab...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Buganim, Yosef, Markoulaki, Styliani, van Wietmarschen, Niek, Hoke, Heather, Wu, Tao, Ganz, Kibibi, Akhtar-Zaidi, Batool, He, Yupeng, Abraham, Brian J., Porubsky, David, Kulenkampff, Elisabeth, Faddah, Dina A., Shi, Linyu, Gao, Qing, Sarkar, Sovan, Cohen, Malkiel, Goldmann, Johanna, Nery, Joseph R., Schultz, Matthew D., Ecker, Joseph R., Xiao, Andrew, Young, Richard A., Lansdorp, Peter M., Jaenisch, Rudolf
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4170792/
https://ncbi.nlm.nih.gov/pubmed/25192464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.07.003
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi