Sequential Eukaryotic Translation Initiation Factor 5 (eIF5) Binding to the Charged Disordered Segments of eIF4G and eIF2β Stabilizes the 48S Preinitiation Complex and Promotes Its Shift to the Initiation Mode

During translation initiation in Saccharomyces cerevisiae, an Arg- and Ser-rich segment (RS1 domain) of eukaryotic translation initiation factor 4G (eIF4G) and the Lys-rich segment (K-boxes) of eIF2β bind three common partners, eIF5, eIF1, and mRNA. Here, we report that both of these segments are in...

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Main Authors: Singh, Chingakham Ranjit, Watanabe, Ryosuke, Chowdhury, Wasimul, Hiraishi, Hiroyuki, Murai, Marcelo J., Yamamoto, Yasufumi, Miles, David, Ikeda, Yuka, Asano, Masayo, Asano, Katsura
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457530/
https://ncbi.nlm.nih.gov/pubmed/22851688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00376-12
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