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Nek4 Regulates Entry into Replicative Senescence and the Response to DNA Damage in Human Fibroblasts
When explanted into culture, normal human cells exhibit a finite number of cell divisions before entering a proliferative arrest termed replicative senescence. To identify genes essential for entry into replicative senescence, we performed an RNA interference (RNAi)-based loss-of-function screen and...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3457524/ https://ncbi.nlm.nih.gov/pubmed/22851694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00436-12 |
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