Nek4 Regulates Entry into Replicative Senescence and the Response to DNA Damage in Human Fibroblasts

When explanted into culture, normal human cells exhibit a finite number of cell divisions before entering a proliferative arrest termed replicative senescence. To identify genes essential for entry into replicative senescence, we performed an RNA interference (RNAi)-based loss-of-function screen and...

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Auteurs principaux: Nguyen, Christine L., Possemato, Richard, Bauerlein, Erica L., Xie, Anyong, Scully, Ralph, Hahn, William C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457524/
https://ncbi.nlm.nih.gov/pubmed/22851694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00436-12
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