Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

Foci of phosphorylated histone H2AX and ATM are the surrogate markers of DNA double strand breaks. We previously reported that the residual foci increased their size after irradiation, which amplifies DNA damage signals. Here, we addressed whether amplification of DNA damage signal is involved in re...

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Bibliographic Details
Main Authors: Suzuki, Masatoshi, Suzuki, Keiji, Kodama, Seiji, Yamashita, Shunichi, Watanabe, Masami
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461254/
https://ncbi.nlm.nih.gov/pubmed/23050037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/310534
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