Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

Foci of phosphorylated histone H2AX and ATM are the surrogate markers of DNA double strand breaks. We previously reported that the residual foci increased their size after irradiation, which amplifies DNA damage signals. Here, we addressed whether amplification of DNA damage signal is involved in re...

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Bibliografische gegevens
Hoofdauteurs: Suzuki, Masatoshi, Suzuki, Keiji, Kodama, Seiji, Yamashita, Shunichi, Watanabe, Masami
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hindawi Publishing Corporation 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461254/
https://ncbi.nlm.nih.gov/pubmed/23050037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/310534
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