Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

Foci of phosphorylated histone H2AX and ATM are the surrogate markers of DNA double strand breaks. We previously reported that the residual foci increased their size after irradiation, which amplifies DNA damage signals. Here, we addressed whether amplification of DNA damage signal is involved in re...

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Detalhes bibliográficos
Main Authors: Suzuki, Masatoshi, Suzuki, Keiji, Kodama, Seiji, Yamashita, Shunichi, Watanabe, Masami
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461254/
https://ncbi.nlm.nih.gov/pubmed/23050037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/310534
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