Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

Foci of phosphorylated histone H2AX and ATM are the surrogate markers of DNA double strand breaks. We previously reported that the residual foci increased their size after irradiation, which amplifies DNA damage signals. Here, we addressed whether amplification of DNA damage signal is involved in re...

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Main Authors: Suzuki, Masatoshi, Suzuki, Keiji, Kodama, Seiji, Yamashita, Shunichi, Watanabe, Masami
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461254/
https://ncbi.nlm.nih.gov/pubmed/23050037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/310534
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