Molecular Basis for Different Levels of tet(M) Expression in Streptococcus pneumoniae Clinical Isolates

Seventy-four unrelated clinical isolates of Streptococcus pneumoniae harboring the tet(M) gene were studied. Seven strains with low tetracycline (Tc) MICs (0.25 to 0.5 μg/ml) were found to harbor truncated tet(M) alleles that were inactivated by different frameshift mutations. In contrast, five stra...

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Главные авторы: Grohs, Patrick, Trieu-Cuot, Patrick, Podglajen, Isabelle, Grondin, Sophie, Firon, Arnaud, Poyart, Claire, Varon, Emmanuelle, Gutmann, Laurent
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2012
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457367/
https://ncbi.nlm.nih.gov/pubmed/22802249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00939-12
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