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Topoisomerase Mutations Associated with In Vitro Selection of Resistance to Moxifloxacin in Streptococcus pneumoniae

We analyzed the frequencies of selection, the order of acquisition, and the mutations selected on moxifloxacin in two wild-type pneumococcal strains, R6 and 5714. The first selection step showed either a single GyrA mutation or no mutation in any of the quinolone resistance-determining regions. Seco...

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Bibliografski detalji
Glavni autori: Houssaye, Serge, Gutmann, Laurent, Varon, Emmanuelle
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC127326/
https://ncbi.nlm.nih.gov/pubmed/12121964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2712-2715.2002
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