A Distinct Smoothened Mutation Causes Severe Cerebellar Developmental Defects and Medulloblastoma in a Novel Transgenic Mouse Model

Deregulated developmental processes in the cerebellum cause medulloblastoma, the most common pediatric brain malignancy. About 25 to 30% of cases are caused by mutations increasing the activity of the Sonic hedgehog (Shh) pathway, a critical mitogen in cerebellar development. The proto-oncogene Smoo...

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Autors principals: Dey, Joyoti, Ditzler, Sally, Knoblaugh, Sue E., Hatton, Beryl A., Schelter, Janell M., Cleary, Michele A., Mecham, Brig, Rorke-Adams, Lucy B., Olson, James M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457348/
https://ncbi.nlm.nih.gov/pubmed/22869526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00862-12
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