Generation of an Adenovirus-Parvovirus Chimera with Enhanced Oncolytic Potential

In this study, our goal was to generate a chimeric adenovirus-parvovirus (Ad-PV) vector that combines the high-titer and efficient gene transfer of adenovirus with the anticancer potential of rodent parvovirus. To this end, the entire oncolytic PV genome was inserted into a replication-defective E1-...

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Autori principali: El-Andaloussi, Nazim, Bonifati, Serena, Kaufmann, Johanna K., Mailly, Laurent, Daeffler, Laurent, Deryckère, François, Nettelbeck, Dirk M., Rommelaere, Jean, Marchini, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Gene Delivery
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457320/
https://ncbi.nlm.nih.gov/pubmed/22787235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00848-12
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