Retargeting of Rat Parvovirus H-1PV to Cancer Cells through Genetic Engineering of the Viral Capsid

The rat parvovirus H-1PV is a promising anticancer agent given its oncosuppressive properties and the absence of known side effects in humans. H-1PV replicates preferentially in transformed cells, but the virus can enter both normal and cancer cells. Uptake by normal cells sequesters a significant p...

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Dettagli Bibliografici
Autori principali: Allaume, Xavier, El-Andaloussi, Nazim, Leuchs, Barbara, Bonifati, Serena, Kulkarni, Amit, Marttila, Tiina, Kaufmann, Johanna K., Nettelbeck, Dirk M., Kleinschmidt, Jürgen, Rommelaere, Jean, Marchini, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Gene Delivery
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302485/
https://ncbi.nlm.nih.gov/pubmed/22258256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06208-11
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