Human Rotavirus-Specific IgM Memory B Cells Have Differential Cloning Efficiencies and Switch Capacities and Play a Role in Antiviral Immunity In Vivo

Protective immunity to rotavirus (RV) is primarily mediated by antibodies produced by RV-specific memory B cells (RV-mBc). Of note, most of these cells express IgM, but the function of this subset is poorly understood. Here, using limiting dilution assays of highly sort-purified human IgM(+) mBc, we...

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Bibliographic Details
Main Authors: Narváez, Carlos F., Feng, Ningguo, Vásquez, Camilo, Sen, Adrish, Angel, Juana, Greenberg, Harry B., Franco, Manuel A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457288/
https://ncbi.nlm.nih.gov/pubmed/22855480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01466-12
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