Human Parvovirus B19 DNA Replication Induces a DNA Damage Response That Is Dispensable for Cell Cycle Arrest at Phase G(2)/M

Human parvovirus B19 (B19V) infection is highly restricted to human erythroid progenitor cells, in which it induces a DNA damage response (DDR). The DDR signaling is mainly mediated by the ATR (ataxia telangiectasia-mutated and Rad3-related) pathway, which promotes replication of the viral genome; h...

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Bibliographische Detailangaben
Hauptverfasser: Lou, Sai, Luo, Yong, Cheng, Fang, Huang, Qinfeng, Shen, Weiran, Kleiboeker, Steve, Tisdale, John F., Liu, Zhengwen, Qiu, Jianming
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457271/
https://ncbi.nlm.nih.gov/pubmed/22837195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01007-12
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