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Hepatitis C Virus (HCV) Induces Formation of Stress Granules Whose Proteins Regulate HCV RNA Replication and Virus Assembly and Egress

Stress granules (SGs) are cytoplasmic structures that are induced in response to environmental stress, including viral infections. Here we report that hepatitis C virus (HCV) triggers the appearance of SGs in a PKR- and interferon (IFN)-dependent manner. Moreover, we show an inverse correlation betw...

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Détails bibliographiques
Auteurs principaux: Garaigorta, Urtzi, Heim, Markus H., Boyd, Bryan, Wieland, Stefan, Chisari, Francis V.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457181/
https://ncbi.nlm.nih.gov/pubmed/22855484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07101-11
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