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Hepatitis C Virus (HCV) Induces Formation of Stress Granules Whose Proteins Regulate HCV RNA Replication and Virus Assembly and Egress

Stress granules (SGs) are cytoplasmic structures that are induced in response to environmental stress, including viral infections. Here we report that hepatitis C virus (HCV) triggers the appearance of SGs in a PKR- and interferon (IFN)-dependent manner. Moreover, we show an inverse correlation betw...

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Detalhes bibliográficos
Main Authors: Garaigorta, Urtzi, Heim, Markus H., Boyd, Bryan, Wieland, Stefan, Chisari, Francis V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457181/
https://ncbi.nlm.nih.gov/pubmed/22855484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07101-11
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