Mutations That Hamper Dimerization of Foot-and-Mouth Disease Virus 3A Protein Are Detrimental for Infectivity

Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. In other picornaviruses, homodimerization of 3A has been shown to be relevant for its biological activity. In this work, FMDV 3A homodimerization was evidenced by an in...

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Detalhes bibliográficos
Main Authors: González-Magaldi, Mónica, Postigo, Raúl, de la Torre, Beatriz G., Vieira, Yuri A., Rodríguez-Pulido, Miguel, López-Viñas, Eduardo, Gómez-Puertas, Paulino, Andreu, David, Kremer, Leonor, Rosas, María F., Sobrino, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457133/
https://ncbi.nlm.nih.gov/pubmed/22787230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00580-12
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