Mutations That Hamper Dimerization of Foot-and-Mouth Disease Virus 3A Protein Are Detrimental for Infectivity

Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. In other picornaviruses, homodimerization of 3A has been shown to be relevant for its biological activity. In this work, FMDV 3A homodimerization was evidenced by an in...

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Auteurs principaux: González-Magaldi, Mónica, Postigo, Raúl, de la Torre, Beatriz G., Vieira, Yuri A., Rodríguez-Pulido, Miguel, López-Viñas, Eduardo, Gómez-Puertas, Paulino, Andreu, David, Kremer, Leonor, Rosas, María F., Sobrino, Francisco
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457133/
https://ncbi.nlm.nih.gov/pubmed/22787230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00580-12
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