Downregulation of aging-related Klotho gene in experimental colitis: the role of TNF and IFN-γ

BACKGROUND & AIMS: Klotho deficiency in hypomorphic KL mice leads to premature senescence and phenotype consistent with impaired mineral homeostasis. Klotho has anti-inflammatory properties protecting from NO-induced endothelial dysfunction, reduces the expression of endothelial adhesion molecul...

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Main Authors: Thurston, Robert D., Larmonier, Claire B., Majewski, Pawel M., Ramalingam, Rajalakshmy, Midura-Kiela, Monica, Laubitz, Daniel, Vandewalle, Alain, Besselsen, David G., Mühlbauer, Marcus, Jobin, Christian, Kiela, Pawel R., Ghishan, Fayez K.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454518/
https://ncbi.nlm.nih.gov/pubmed/20004202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.12.002
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